BIG 2-97 IES

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BIG 2-97 IES is a randomised double-blind trial in postmenopausal women with primary breast cancer who have received adjuvant tamoxifen for 2-3 years, comparing subsequent adjuvant exemestane treatment with further tamoxifen.

The study found that in postmenopausal women, switching to exemestane after 2-3 years of tamoxifen significantly improves disease-free survival (New England Journal of Medicine 2004) and OS (ASCO 2006).

Coordinating group: ICCG

Patients accrual
Start date: February 1998
Closure date: February 2003
Target nr. of patients: 4740
Final accrual: 4743

Status: closed Identifier: NCT00038467