SOFT & TEXT

Intro text: 

New treatment options for young women with breast cancer

Content: 

The international randomised SOFT/TEXT clinical trials – together involving 5,738 patients from 510 hospitals and cancer centres linked to 13 BIG groups  in 27 countries – were developed in parallel to test the optimal adjuvant endocrine treatment in premenopausal women with hormone-sensitive early breast cancer. SOFT and TEXT are led by the International Breast Cancer Study Group (IBCSG), under the BIG umbrella.

These trials demonstrated that, when combined with ovarian function suppression, exemestane, compared to tamoxifen  significantly improved patient disease outcome, reducing the risk of cancer recurrence by 34%. Patients with a high risk of relapse who had received adjuvant chemotherapy especially benefitted from this treatment. 

Editor: 

The primary results of SOFT and TEXT, which were published in the New England Journal of Medicine in 2014, were supported by a 5-year analysis presented at the 2017 San Antonio Breast Cancer Symposium.

While the patient follow-up continues, SOFT and TEXT have already delivered practice-changing results, providing a new post-operative treatment option for young women with hormone-sensitive early breast cancer who may have a higher risk of cancer recurrence after surgery.

Main Publications

SOFT/TEXT trials testing the optimal adjuvant endocrine treatment for young women with hormone-sensitive early breast cancer